Search on: PROCOLLAGEN-PROLINE DIOXYGENASE 
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Descriptor English:   Procollagen-Proline Dioxygenase 
Descriptor Spanish:   Procolágeno-Prolina Dioxigenasa 
Descriptor Portuguese:   Pró-Colágeno-Prolina Dioxigenase 
Synonyms English:   4-Hydroxylase, Procollagen Prolyl
Dioxygenase, Procollagen-Proline
Hydroxylase, Protocollagen Prolyl
Procollagen Proline Dioxygenase
Procollagen Prolyl 4 Hydroxylase
Procollagen Prolyl 4-Hydroxylase
Prolyl 4-Hydroxylase, Procollagen
Prolyl Hydroxylase, Protocollagen
Protocollagen Prolyl Hydroxylase  
Tree Number:   D08.811.682.690.416.617.750
D08.811.682.690.708.694.750
Definition English:   A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES. 
See Related English:   Protein Disulfide-Isomerases
 
History Note English:   94; was PROLINE HYDROXYLASE 1972-93 (Prov 1972-73); PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE was PROLINE,2-OXOGLUTARATE DIOXYGENASE see PROLINE HYDROXYLASE 1977-93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   31898 
Unique Identifier:   D011393 

Occurrence in VHL:
 

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